You should try targeting them based on metrics such as who click which links, what pages they visit, what they buy, and so forth. This will prevent mailing list you from sending out the wrong message to the wrong people, and help increase responsiveness in the process. Righting the Wrongs Should you botch segmentation for whatever reason, do not panic, because there are some things you can do to make up for it.
Keep the following tips in mind, and you should be able to right those wrongs: Come clean - If a segmentation error led to subscribers getting content they were not supposed to receive, the best thing you can do is come clean and own mailing list up to the mistake. Sure, you screwed up, but consumers appreciate honesty. Email marketing is all about building trust and showing that you are human like everyone else gives you a better chance of earning it. Make your move.
So, you messed up with segmentation. What are you doing to do about it now? Send a follow-up email that contains a counter-offer? If that offer is not going to completely rectify the problem, you may be better served just offering an apology mailing list and moving forward. We all make a mistake every now and then, but lingering on it could end up doing more harm than good.